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Related Concept Videos

Cross-bridge Cycle01:26

Cross-bridge Cycle

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As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
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Chemical Synapses01:26

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Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
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Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
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Disorders of the Skeletal Muscle01:28

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
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Neuralgic amyotrophy.

Jos IJspeert1, Renske M J Janssen2, Nens van Alfen3

  • 1Department of Rehabilitation, Donders Institute for Brain, Cognition and Behavior.

Current Opinion in Neurology
|May 31, 2021
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Summary

Neuralgic amyotrophy (NA) is an underdiagnosed autoimmune nerve disorder. Early treatment and rehabilitation are crucial for managing long-term symptoms and preventing permanent impairment.

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Area of Science:

  • Neurology
  • Immunology
  • Peripheral Nervous System Disorders

Background:

  • Neuralgic amyotrophy (NA) is an autoimmune disorder affecting the peripheral nervous system.
  • It can lead to significant and permanent patient impairment if not promptly diagnosed and managed.

Purpose of the Study:

  • To review current insights and developments in neuralgic amyotrophy (NA).
  • To highlight the importance of early recognition and proper treatment for optimal patient outcomes.

Main Methods:

  • Literature review of recent studies on neuralgic amyotrophy.
  • Analysis of diagnostic advancements, particularly in nerve imaging.
  • Evaluation of treatment strategies, including immunomodulatory therapies and rehabilitation.

Main Results:

  • NA is more common than previously thought, often presenting as acute nerve palsies.
  • Phrenic nerve involvement occurs in 8% of cases, potentially causing severe disability.
  • While acute treatments may help, long-term symptoms often stem from nerve endurance and altered movement patterns.

Conclusions:

  • Early immunomodulatory treatment and identification of specific nerve involvement (e.g., phrenic neuropathy) are vital for recovery.
  • Persistent symptoms require targeted rehabilitation focusing on energy balance and movement coordination.
  • Surgical options exist for nerves that do not recover spontaneously.