[Risk factors for clinical deterioration in patients admitted for COVID-19: A case-control study]

Area of Science:

• Infectious Diseases
• Pulmonology
• Critical Care Medicine

Context:

• COVID-19 pandemic has led to significant hospitalizations.
• Predicting clinical deterioration in hospitalized COVID-19 patients remains a challenge.
• Identifying high-risk patients is essential for timely intervention.

Purpose:

• To identify predictors and risk factors for clinical deterioration in hospitalized COVID-19 patients.
• To develop a model for predicting adverse outcomes in COVID-19.

Summary:

• A nested case-control study identified key predictors of COVID-19 deterioration.
• Significant risk factors include low emergency department oxygen saturation, abnormal chest X-ray, high CRP, thrombocytopenia, and history of myocardial infarction, COPD, or hypertension.
• The predictive model demonstrated good performance with an AUC of 0.86.

Impact:

• Identified variables can aid clinicians in detecting high-risk COVID-19 patients.
• Early identification facilitates prompt management and potentially improves patient outcomes.
• Findings contribute to better resource allocation and treatment strategies for severe COVID-19.