Performance of Primary Angioplasty for STEMI during the COVID-19 Outbreak
Surya Dharma1, Iwan Dakota2, Isman Firdaus2
1Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.
Insights
During the COVID-19 outbreak, ST-segment elevation myocardial infarction (STEMI) cases declined, impacting primary angioplasty performance. While door-to-device times increased, key outcomes like TIMI 3 flow and in-hospital mortality remained similar, supporting angioplasty as standard care.
Area of Science:
- Cardiology
- Interventional Cardiology
- Public Health
Background:
- The COVID-19 pandemic led to concerns about the impact on acute myocardial infarction care.
- Declining ST-segment elevation myocardial infarction (STEMI) admissions raised questions about primary angioplasty effectiveness during the outbreak.
Purpose of the Study:
- To assess primary angioplasty performance for STEMI patients during the COVID-19 outbreak compared to the pre-outbreak period.
- To evaluate door-to-device (DTD) times and thrombolysis in myocardial infarction (TIMI) flow outcomes.
Main Methods:
- A comparative study analyzing STEMI admissions and primary angioplasty data from March 1 to May 31, 2020 (outbreak) versus March 1 to May 31, 2019 (pre-outbreak).
- Key metrics included STEMI admission rates, DTD time, symptom onset-to-admission time, radial access uptake, infarct-related artery, TIMI flow, and in-hospital mortality.
Main Results:
- STEMI admissions decreased by 44% during the COVID-19 outbreak.
- Median DTD time and total ischemia time were significantly longer during the outbreak (104 vs. 81 minutes, p < 0.001).
- Final TIMI 3 flow achievement (87.1% vs. 87.2%) and in-hospital mortality (5.7% vs. 7.8%) were similar between the two periods.
Conclusions:
- Despite longer DTD times during the COVID-19 outbreak, primary angioplasty maintained similar procedural success and patient outcomes.
- Primary angioplasty remains the recommended standard of care for STEMI management, even during public health emergencies like the COVID-19 pandemic.
Abstract:
There has been concern whether the declining cases of ST-segment elevation myocardial infarction (STEMI) during the coronavirus disease 2019 (COVID-19) outbreak associate with primary angioplasty performance. We assessed the performance of primary angioplasty in a tertiary care hospital in Jakarta, Indonesia, by comparing the door-to-device (DTD) time and thrombolysis in myocardial infarction (TIMI) flow after angioplasty between two periods of admission: during the outbreak of COVID-19 (March 1 to May 31, 2020) and before the outbreak (March 1, to May 31, 2019). Overall, there was a relative reduction of 44% for STEMI admission during the outbreak ( n = 116) compared with before the outbreak ( N = 208). Compared with before the outbreak period ( n = 141), STEMI patients who admitted during the outbreak and received primary angioplasty ( n = 70) had similar median symptom onset-to-angioplasty center admission (360 minutes for each group), similar to radial access uptake (90 vs. 89.4%, p = 0.88) and left anterior descending infarct-related artery (54.3 vs. 58.9%, p = 0.52). The median DTD time and total ischemia time were longer (104 vs. 81 minutes, p < 0.001, and 475.5 vs. 449 minutes, p = 0.43, respectively). However, the final achievement of TIMI 3 flow was similar (87.1 vs. 87.2%), and so was the in-hospital mortality (5.7 vs. 7.8%). During the COVID-19 outbreak, we found a longer DTD time for primary angioplasty, but the achievement of final TIMI 3 flow and in-hospital mortality were similar as compared with before the outbreak. Thus, primary angioplasty should remain the standard of care for STEMI during the COVID-19 outbreak.
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