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Will Remdesivir Reshape Cardiovascular Practice in COVID 19 Era?
A Mohammed Idhrees1, Prasanna Karthik Suthakaran2, George Jose Valooran3
1Institute of Cardiac and Aortic Disorders, SRM Institutes for Medical Science (SIMS Hospital), Chennai, Tamil Nadu, India.
Summary
This review examines remdesivir
Area of Science:
- Cardiology
- Infectious Diseases
- Pharmacology
Background:
- COVID-19, caused by SARS-CoV-2, is a systemic illness.
- It triggers hyperinflammation and cytokine storm, impacting organs like the myocardium.
- Elevated cardiac biomarkers and thromboembolic events are observed in COVID-19 patients, increasing mortality risk, especially in those with cardiovascular disease.
Purpose of the Study:
- To provide a comprehensive review of remdesivir.
- To explore its association with cardiovascular disease.
- To highlight its potential implications for cardiovascular medicine and surgery.
Main Methods:
- Literature review of studies on remdesivir and cardiovascular disease.
- Analysis of scientific data up to June 17, 2020.
- Focus on the drug's mechanism and clinical impact.
Main Results:
- COVID-19 significantly affects cardiovascular health, indicated by biomarker changes and thrombosis.
- The impact of remdesivir on cardiovascular outcomes remains largely unknown.
- This review synthesizes current knowledge on remdesivir's cardiovascular associations.
Conclusions:
- Understanding remdesivir's cardiovascular effects is crucial for managing COVID-19 patients.
- Further research is needed to clarify its role in cardiovascular medicine and surgery.
- This review serves as a timely resource in a rapidly evolving field.
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