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Will Remdesivir Reshape Cardiovascular Practice in COVID 19 Era?

A Mohammed Idhrees1, Prasanna Karthik Suthakaran2, George Jose Valooran3

  • 1Institute of Cardiac and Aortic Disorders, SRM Institutes for Medical Science (SIMS Hospital), Chennai, Tamil Nadu, India.

The International Journal of Angiology : Official Publication of the International College of Angiology, Inc
|May 31, 2021
PubMed

Insights

This review examines remdesivir

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pharmacology

Background:

  • COVID-19, caused by SARS-CoV-2, is a systemic illness.
  • It triggers hyperinflammation and cytokine storm, impacting organs like the myocardium.
  • Elevated cardiac biomarkers and thromboembolic events are observed in COVID-19 patients, increasing mortality risk, especially in those with cardiovascular disease.

Purpose of the Study:

  • To provide a comprehensive review of remdesivir.
  • To explore its association with cardiovascular disease.
  • To highlight its potential implications for cardiovascular medicine and surgery.

Main Methods:

  • Literature review of studies on remdesivir and cardiovascular disease.
  • Analysis of scientific data up to June 17, 2020.
  • Focus on the drug's mechanism and clinical impact.

Main Results:

  • COVID-19 significantly affects cardiovascular health, indicated by biomarker changes and thrombosis.
  • The impact of remdesivir on cardiovascular outcomes remains largely unknown.
  • This review synthesizes current knowledge on remdesivir's cardiovascular associations.

Conclusions:

  • Understanding remdesivir's cardiovascular effects is crucial for managing COVID-19 patients.
  • Further research is needed to clarify its role in cardiovascular medicine and surgery.
  • This review serves as a timely resource in a rapidly evolving field.

Keywords:
COVID-19SARS-CoV2cardiovascular medicinecardiovascular surgerycoronavirusremdesivir

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