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C Hanriat1,2, C Barani1,2, A Mojallal2

  • 1Centre de Traitement des Brûlés Pierre Colson, Hôpital Édouard Herriot, Lyon, France.

Annals of Burns and Fire Disasters
|May 31, 2021
PubMed
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Platelet-rich plasma (PRP) shows promise for burn wound healing. Clinical studies and animal models indicate PRP can accelerate healing, improve skin graft outcomes, and enhance distant skin health.

Area of Science:

  • Regenerative Medicine
  • Wound Healing Research

Context:

  • Burn injuries present significant challenges in healing and recovery.
  • Platelet-rich plasma (PRP) contains growth factors with potential therapeutic applications.
  • The Lyon Burn Centre is preparing a clinical study on PRP for burn wound management.

Purpose:

  • To review existing literature on the efficacy of Platelet-rich Plasma (PRP) in treating burn injuries.
  • To evaluate preclinical and clinical evidence for PRP's role in burn healing and pain management.

Summary:

  • A literature review identified 11 studies (8 preclinical, 3 clinical) on PRP for burns.
  • Preclinical data suggest PRP accelerates epithelialization.
  • Clinical studies show PRP benefits in combination with skin grafts and for distant cutaneous trophicity.

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Impact:

  • Topical or subcutaneous PRP application may benefit acute burn management.
  • Evidence supports PRP's potential in improving burn healing and skin health.
  • A large clinical series validates PRP's use in practice for burns.