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Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Achieving Quiescence with Fluocinolone Implants.

Freia McGregor1, Andrew D Dick1, Tomas Burke1

  • 1Bristol Eye Hospital, Bristol, United Kingdom.

Case Reports in Ophthalmology
|May 31, 2021
PubMed
Summary
This summary is machine-generated.

A new fluocinolone acetonide implant effectively treated persistent uveitis and macular edema in a steroid-dependent patient. This treatment achieved disease quiescence even during an acute relapse, offering a new option for refractory cases.

Keywords:
Fluocinolone acetonideIntraocular inflammationUveitis

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Area of Science:

  • Ophthalmology
  • Immunology
  • Pharmacology

Background:

  • Persistent anterior uveitis can lead to cystoid macular edema, often requiring immunosuppression.
  • Refractory and steroid-dependent cases present significant treatment challenges.

Observation:

  • A case report details the use of a fluocinolone acetonide (Iluvien®) implant in a patient with refractory, steroid-dependent uveitis and cystoid macular edema.
  • The patient experienced an acute relapse during treatment.

Findings:

  • The fluocinolone acetonide implant successfully induced quiescence in the persistent uveitis and cystoid macular edema.
  • The treatment was effective despite the patient's steroid dependency and the acute relapse.

Implications:

  • This highlights fluocinolone acetonide as a potential therapeutic option for difficult-to-treat uveitis and associated macular edema.
  • The findings suggest sustained intraocular drug delivery can manage chronic inflammatory eye conditions effectively.