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De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
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Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
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Corrigendum: Metabolic Reprogramming Promotes Myogenesis During Aging.

Roberta Belli1, Agnese Bonato2, Luciana De Angelis3

  • 1Department of Translational and Precision Medicine (Formerly Department of Clinical Medicine), Sapienza University of Rome, Rome, Italy.

Frontiers in Physiology
|May 31, 2021
PubMed
Summary

This study corrects a previous article DOI. The corrected DOI ensures accurate citation and retrieval of the research findings for enhanced scientific discovery.

Keywords:
agingmetabolic reprogrammingmetabolismmitochondriamyogenesisneuromuscular activitysarcopeniatrimetazidine

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Area of Science:

  • Physiology
  • Biomedical Research

Context:

  • Correction of a previously published article DOI.
  • Ensuring accurate citation and accessibility of scientific literature.

Purpose:

  • To provide the correct Digital Object Identifier (DOI) for the article.
  • To rectify errors in the published record.

Summary:

  • The article DOI: 10.3389/fphys.2019.00897 has been corrected.
  • This correction facilitates proper referencing and access to the research.

Impact:

  • Improved accuracy in scientific citations.
  • Enhanced discoverability and retrieval of research articles.
  • Maintained integrity of the scientific record.