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Transforming Growth Factor-β and Long Non-coding RNA in Renal Inflammation and Fibrosis

Yue-Yu Gu1,2, Jing-Yun Dou1,3, Xiao-Ru Huang2,4

  • 1Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.

Frontiers in Physiology
|May 31, 2021
PubMed

Insights

Transforming growth factor-β (TGF-β) and long non-coding RNAs (lncRNAs) are key players in chronic kidney disease (CKD) fibrosis and inflammation. Targeting these molecules offers potential therapeutic strategies and biomarkers for kidney disease.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Genetics

Background:

  • Renal fibrosis is a hallmark of chronic kidney disease (CKD), often leading to kidney failure.
  • Transforming growth factor-β (TGF-β) is a critical mediator of renal fibrosis and inflammation.
  • Broad TGF-β inhibition may cause adverse effects due to its diverse roles.

Purpose of the Study:

  • To review the roles of TGF-β and long non-coding RNAs (lncRNAs) in renal fibrosis and inflammation.
  • To highlight their potential as therapeutic targets and biomarkers for CKD.

Main Methods:

  • Literature review focusing on TGF-β and lncRNAs in renal pathology.
  • Analysis of the molecular mechanisms underlying renal fibrosis and inflammation.
  • Evaluation of therapeutic and diagnostic potential.

Main Results:

  • TGF-β is central to fibrogenesis and inflammation in the kidney.
  • lncRNAs emerge as significant regulators in these processes.
  • Both TGF-β and lncRNAs show promise as therapeutic targets and biomarkers.

Conclusions:

  • Targeting TGF-β and lncRNAs presents a promising avenue for managing renal fibrosis in CKD.
  • Further research into these molecules could lead to novel treatments and diagnostic tools for kidney diseases.
Keywords:
SMADsTGF-βinflammationlong non-coding RNAmolecular therapyrenal fibrosis

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