Changes in Circadian Rhythms Dysregulate Inflammation in Ageing: Focus on Leukocyte Trafficking
Poppy Nathan1, Julie Elizabeth Gibbs2, G Ed Rainger3
1MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
Frontiers in Immunology
|May 31, 2021
Summary
Aging disrupts leukocyte trafficking rhythms, contributing to chronic inflammation. This review explores how age-related circadian rhythm changes impact immune function and inflammatory disorders.
Area of Science:
- Immunology
- Chronobiology
- Aging Biology
Background:
- Leukocyte trafficking exhibits strong diurnal rhythmicity, regulated by circadian rhythms.
- Aging is linked to dysregulated leukocyte trafficking, chronic inflammation, and diminished circadian outputs.
- The direct impact of age-associated circadian dampening on leukocyte trafficking dysregulation is not well understood.
Purpose of the Study:
- To review the mammalian circadian clock machinery and its age-related changes.
- To focus on how leukocyte trafficking rhythmicity changes with age.
- To consider the impact on inflammation and immune-mediated inflammatory disorders (IMIDs).
Main Methods:
- Review of core mammalian circadian clock machinery.
- Analysis of age-associated changes in circadian systems.
- Examination of leukocyte trafficking rhythmicity in aging.
Main Results:
- Aging leads to dysregulation of leukocyte trafficking and diminished circadian rhythms.
- Age-related changes in circadian outputs may impact immune cell behavior.
- The link between circadian rhythm dampening and leukocyte trafficking dysregulation in aging requires further investigation.
Conclusions:
- Age-related circadian changes may contribute to chronic inflammation and IMIDs.
- Further research incorporating a circadian approach is needed in aging biology.
- Understanding these connections is crucial for elucidating the role of aging circadian changes in IMID development.
More Related Videos
06:50The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
Published on: July 24, 2018
7.7K
09:01Assessing Leukocyte-endothelial Interactions Under Flow Conditions in an Ex Vivo Autoperfused Microflow Chamber Assay
Published on: December 30, 2014
9.8K
Related Concept Videos
02:19Circadian Rhythms and Gene Regulation
4.2K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.2K
01:38Inflammation
56.9K
Overview
56.9K
01:28Inflammatory Response
14.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
14.1K
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
179
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
179
01:26Aging
380
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
380
01:19The Effect of Aging on Tissues
2.9K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.9K