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Related Experiment Videos

Morning sickness and thyroid function in normal pregnancy.

M Mori1, N Amino, H Tamaki

  • 1Department of Obstetrics and Gynecology, Osaka University Medical School, Japan.

Obstetrics and Gynecology
|September 1, 1988
PubMed
Summary

Early pregnancy involves physiological thyroid activation, evidenced by increased free thyroxine (T4) and decreased thyroid-stimulating hormone (TSH). These thyroid changes correlate with morning sickness severity and are likely influenced by human chorionic gonadotropin (hCG).

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Area of Science:

  • Endocrinology
  • Reproductive Medicine
  • Biochemistry

Background:

  • Thyroid function undergoes significant physiological changes during pregnancy.
  • The relationship between thyroid hormones, human chorionic gonadotropin (hCG), and gestational symptoms like morning sickness requires further elucidation.

Purpose of the Study:

  • To evaluate thyroid function (free thyroxine [T4] and thyroid-stimulating hormone [TSH]) in early normal pregnancy.
  • To investigate the correlation between thyroid hormone levels, hCG, and the severity of morning sickness.
  • To differentiate physiological thyroid changes in pregnancy from thyrotoxicosis.

Main Methods:

  • Utilized a newly developed radioimmunoassay for free thyroxine (T4).
  • Employed a highly sensitive immunoradiometric assay for TSH.

Related Experiment Videos

  • Compared thyroid function parameters in pregnant individuals with nonpregnant controls and correlated them with hCG levels and morning sickness severity.

    • Main Results:

    • Observed a significant increase in serum free T4 and a decrease in serum TSH in early pregnancy compared to nonpregnant controls.
    • Found that elevated free T4 and decreased TSH levels correlated with the severity of morning sickness, particularly nausea and vomiting.
    • Demonstrated significant positive correlation between individual serum hCG levels and free T4, and an inverse correlation with TSH.

    Conclusions:

    • Early pregnancy involves physiological thyroid gland activation, potentially stimulated by hCG or related substances, which may contribute to gestational emesis.
    • Increased free T4 and reduced TSH in early normal pregnancy are physiological adaptations and not indicative of thyrotoxicosis, thus not requiring antithyroid drug treatment.