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Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
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KSHV Reprogramming of Host Energy Metabolism for Pathogenesis
Xiaoqing Liu1, Caixia Zhu1, Yuyan Wang1
1Ministry of Education (MOE) & National Health Committee (NHC) & Chinese Academy of Medical Science (CAMS), Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medicine, Shanghai Medical College, Fudan University, Shanghai, China.
Frontiers in Cellular and Infection Microbiology
|May 31, 2021
Summary
Kaposi's sarcoma-associated herpesvirus (KSHV) alters host cell metabolism, including glycolysis and fatty acid synthesis, to fuel viral replication and cancer growth. Targeting these metabolic pathways offers new strategies for treating KSHV-associated cancers.
Area of Science:
- Oncology
- Virology
- Metabolic pathways
Background:
- Reprogramming of energy metabolism is crucial for cancer development.
- Kaposi's sarcoma-associated herpesvirus (KSHV) is linked to human malignancies, infecting B-lymphocytes and endothelial cells.
- Key metabolic pathways in cancer include aerobic glycolysis, glutaminolysis, and fatty acid synthesis.
Purpose of the Study:
- To review how KSHV infection alters host cell metabolism.
- To explore the role of metabolic reprogramming in KSHV pathogenesis.
- To identify potential therapeutic targets for KSHV-associated cancers.
Main Methods:
- This review synthesizes findings from recent studies.
- Literature search focused on KSHV infection and host cell metabolism.
- Analysis of metabolic pathways affected by KSHV.
Main Results:
- KSHV infection significantly alters central carbon metabolism.
- Altered pathways support viral replication and infected cell survival/proliferation.
- Specific pathways manipulated include aerobic glycolysis, glutaminolysis, and fatty acid synthesis.
Conclusions:
- KSHV manipulates host metabolism to promote viral pathogenesis.
- Understanding these metabolic alterations provides therapeutic avenues.
- Targeting metabolic pathways is a promising strategy for KSHV-associated cancers.
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