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Visualizing the Actin and Microtubule Cytoskeletons at the B-cell Immune Synapse Using Stimulated Emission Depletion STED Microscopy
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Ecm29-Dependent Proteasome Localization Regulates Cytoskeleton Remodeling at the Immune Synapse

Jorge Ibañez-Vega1, Felipe Del Valle1, Juan José Sáez1

  • 1Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

Frontiers in Cell and Developmental Biology
|May 31, 2021
PubMed
Summary

B cells use proteasomes to control actin dynamics at the immune synapse (IS). Ecm29 protein regulates proteasome distribution, impacting antigen capture and cell spreading.

Keywords:
B cellEcm29actin cytoskeletonimmune synapselysosomesmicrotubulesproteasome

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