Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.0K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.0K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

779
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
779

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Indocyanine green angiography and machine learning analysis determine topographic distribution of peripheral hard drusen in a Chinese cohort.

Communications medicine·2026
Same author

Liproxstatin-1 Attenuates Retinal Ischemia-Reperfusion Injury by Suppressing EGR1-Mediated Ferroptosis.

Antioxidants (Basel, Switzerland)·2026
Same author

Efficacy and safety of ultrasound cycloplasty as the first treatment in glaucoma for eyes with functional vision: A 1-year prospective study.

Advances in ophthalmology practice and research·2026
Same author

Synergistic Suppression of Choroidal Neovascularization by Cavtratin and Aflibercept via Inhibition of the eNOS Pathway.

Current eye research·2025
Same author

Aqueous Humor Cytokine Levels as Prognostic Factors for Ultrasound Cycloplasty Outcomes in Primary Glaucoma Patients.

Ophthalmic research·2025
Same author

Peripheral Iridectomy With Goniosynechialysis and Goniotomy vs Trabeculectomy for Advanced PACG: A Randomized Clinical Trial.

JAMA ophthalmology·2025
Same journal

Posterior capsule rupture with complete lens dislocation into the vitreous cavity caused by blunt trauma: a case report.

Frontiers in medicine·2026
Same journal

Case Report: Heparin resistance as the harbinger of heparin-induced thrombocytopenia in acute pulmonary embolism.

Frontiers in medicine·2026
Same journal

Trends and variation in use of end-tidal carbon dioxide during in-hospital cardiac arrest: an observational cohort study.

Frontiers in medicine·2026
Same journal

From virtual pregnancy to digital twin obstetrics: multimodal data integration for personalized prediction of pregnancy complications.

Frontiers in medicine·2026
Same journal

Immunotherapy with or without low-intensity chemotherapy versus conventional chemotherapy as first-line treatment for newly diagnosed B-ALL patients fit for intensive chemotherapy: a propensity score-matched study.

Frontiers in medicine·2026
Same journal

Hypertension and frailty in older adults: a bibliometric analysis and knowledge mapping based on Web of Science, Scopus, and PubMed (1973-2025).

Frontiers in medicine·2026
See all related articles

Related Experiment Video

Updated: Nov 4, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.5K

Low-Contrast High-Pass Visual Acuity Might Help to Detect Glaucoma Damage: A Structure-Function Analysis.

Yun Wen1, Zidong Chen1, Chengguo Zuo1

  • 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Frontiers in Medicine
|May 31, 2021
PubMed
Summary
This summary is machine-generated.

Low-contrast high-pass visual acuity (VA) tests are more sensitive for detecting glaucoma-related macular damage than standard VA tests. This method correlates better with retinal ganglion cell loss in glaucoma patients.

Keywords:
glaucomahigh-pass optotypeslow-contrast visual acuitymacular damageoptical coherence tomography

More Related Videos

Author Spotlight: Assessment of Visual Acuity in Central Vision Loss Through Motion-Based Peripheral Vision Testing
06:25

Author Spotlight: Assessment of Visual Acuity in Central Vision Loss Through Motion-Based Peripheral Vision Testing

Published on: February 23, 2024

811
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

3.1K

Related Experiment Videos

Last Updated: Nov 4, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.5K
Author Spotlight: Assessment of Visual Acuity in Central Vision Loss Through Motion-Based Peripheral Vision Testing
06:25

Author Spotlight: Assessment of Visual Acuity in Central Vision Loss Through Motion-Based Peripheral Vision Testing

Published on: February 23, 2024

811
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

3.1K

Area of Science:

  • Ophthalmology
  • Neuroscience

Background:

  • Conventional visual acuity (VA) testing lacks sensitivity for detecting early macular damage in glaucoma.
  • Glaucoma is a progressive optic neuropathy characterized by retinal ganglion cell loss and visual field defects.

Purpose of the Study:

  • To evaluate the sensitivity of low-contrast high-pass optotypes for detecting macular dysfunction in glaucoma.
  • To identify the structural basis for differences in VA measurements between conventional and low-contrast high-pass tests.

Main Methods:

  • Recruited 147 participants (118 glaucoma patients, 29 healthy controls).
  • Measured best-corrected VA using conventional and low-contrast high-pass charts (1.25% contrast).
  • Assessed macular retinal thickness and circumpapillary retinal nerve fiber layer (cpRNFL) using spectral-domain optical coherence tomography (SD-OCT).

Main Results:

  • Glaucoma patients showed significantly worse VA with high-pass charts compared to controls.
  • 1.25% low-contrast high-pass VA optimally discriminated between groups (AUC: 0.918, sensitivity: 77.33%, specificity: 96.55%).
  • 1.25% high-pass VA correlated better with macular retinal ganglion cell (RGC) parameters than conventional VA.

Conclusions:

  • Low-contrast (1.25%) high-pass VA testing is more sensitive for detecting central visual loss in glaucoma.
  • Macular RGC damage is associated with visual loss detected by low-contrast high-pass VA in glaucoma.