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Cancer-Associated circRNA-miRNA-mRNA Regulatory Networks: A Meta-Analysis

Shaheerah Khan1,2, Atimukta Jha1,3, Amaresh C Panda1

  • 1Institute of Life Sciences, Bhubaneswar, India.

Frontiers in Molecular Biosciences
|May 31, 2021
PubMed

Insights

Circular RNAs (circRNAs) play a key role in cancer development by regulating gene expression through microRNAs (miRNAs). This study identifies crucial circRNA-miRNA-mRNA interactions driving various cancers.

Area of Science:

  • Molecular Biology
  • Genomics
  • Cancer Research

Background:

  • Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are increasingly recognized for their roles in cancer.
  • Circular RNAs (circRNAs) are stable, closed-loop molecules that regulate gene expression by interacting with miRNAs and RNA-binding proteins (RBPs) or by translating into proteins.

Purpose of the Study:

  • To investigate the interactions among circRNAs, miRNAs, and their target messenger RNAs (mRNAs) in various cancers.
  • To identify key regulatory elements within the circRNA-miRNA-mRNA axis that contribute to tumorigenesis and metastasis.

Main Methods:

  • Utilized advanced bioinformatics tools to analyze publicly available cancer genomic data.
  • Identified differentially expressed circRNAs, miRNAs, and mRNAs across multiple cancer types.

Main Results:

  • Discovered numerous critical driver and tumor suppressor genes involved in the circRNA-miRNA-mRNA regulatory network.
  • Established specific circRNA-miRNA-mRNA axes implicated in the pathogenesis of various cancers.

Conclusions:

  • The findings provide a comprehensive understanding of circRNA-miRNA-mRNA regulatory mechanisms in cancer.
  • Highlights the potential of targeting these interactions for cancer diagnostics and therapeutics.
Keywords:
TCGAcancercircRNAdriver genesmicroRNAtumor suppressor genes

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