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Psoriasis Exacerbation after Candida Antigen Immunotherapy Injection
Sameh Magdy Sarsik1, Sarah Hamdy Soliman1
1Dermatology and Venereology department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Skin Appendage Disorders
|May 31, 2021
Summary
Candida antigen immunotherapy for warts can trigger psoriasis flare-ups. Healthcare providers should consider alternative treatments for patients prone to psoriasis due to potential immune system alterations.
Area of Science:
- Dermatology
- Immunology
- Wart Treatment
Background:
- Immunotherapy is a proposed effective and well-tolerated treatment for warts.
- Systemic immune activation may occur with immunotherapy, potentially altering a patient's immune state.
Observation:
- A 29-year-old patient experienced psoriasis exacerbation and psoriatic arthritis shortly after receiving Candida antigen immunotherapy for filiform warts.
Findings:
- Candida antigen injection may precipitate psoriasis exacerbation.
- Tumor necrosis factor-alpha (TNFα) and T-helper 1 induction are common pathways in both psoriasis and Candida antigen immunotherapy.
Implications:
- Caution is advised when using Candida antigen immunotherapy in patients susceptible to psoriasis.
- Meticulous follow-up is recommended, or alternative treatments should be considered for wart management in these individuals.
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