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Treatment of Heart Failure With Mid-Range Ejection Fraction: A Summary of Current Evidence

Teng Ma1, Yang Su1, Jing Song2

  • 1Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Frontiers in Cardiovascular Medicine
|May 31, 2021
PubMed

Insights

Heart failure with mid-range ejection fraction (HFmrEF) is a distinct heart failure type. Patients with HFmrEF may benefit more from heart failure with reduced ejection fraction therapies.

Area of Science:

  • Cardiology
  • Heart Failure Research

Background:

  • Heart failure (HF) poses a significant public health challenge.
  • Left ventricular ejection fraction (LVEF) is key for HF assessment.
  • The European Society of Cardiology defined HF with mid-range ejection fraction (HFmrEF) in 2016, a distinct phenotype between HFpEF and HFrEF.

Purpose of the Study:

  • To review current knowledge on HFmrEF treatment.
  • To discuss future directions for defining this unique HF phenotype.

Main Methods:

  • Literature review of studies on HFmrEF.
  • Analysis of treatment benefits in HFmrEF patients.

Main Results:

  • HFmrEF patients may respond better to therapies typically used for HFrEF compared to HFpEF.
  • This phenotype represents a potential transitional state between HFpEF and HFrEF.

Conclusions:

  • Further research is needed to fully characterize HFmrEF.
  • Optimizing treatment strategies for HFmrEF requires a better understanding of its specific mechanisms and patient population.

Keywords:
HFPEFHFmrEFheart failurereviewtreatment

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