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Updated: Nov 4, 2025

Quantifying the Binding Interactions Between CuII and Peptide Residues in the Presence and Absence of Chromophores

Quantifying the Binding Interactions Between CuII and Peptide Residues in the Presence and Absence of Chromophores

Published on: April 5, 2022

Highly Sensitive and Selective Spiropyran-Based Sensor for Copper(II) Quantification.

Kimberly M Trevino¹, Brandon K Tautges¹, Rohan Kapre²

¹Chemistry Graduate Group, University of California at Davis, One Shields Ave, Davis, California 95616, United States.

|May 31, 2021

Summary

This summary is machine-generated.

This study introduces a new colorimetric sensor, dimethylamine-functionalized spiropyran (SP1), for detecting copper ions (Cu2+). SP1 enables sensitive and selective copper detection, making it suitable for field applications.

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Last Updated: Nov 4, 2025

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Area of Science:

Materials Science
Analytical Chemistry
Chemical Sensing

Background:

Spiropyran molecular switches exhibit metal-binding properties for applications in sensing.
Sensitive metal detection for field-based assays remains a challenge.
Copper ion (Cu2+) detection is crucial for environmental and industrial monitoring.

Purpose of the Study:

To develop a colorimetric sensor for sensitive and selective copper ion detection.
To investigate the metal-sensing capabilities of dimethylamine-functionalized spiropyran (SP1).
To assess the viability of SP1 for field-based trace copper analysis.

Main Methods:

Synthesis of dimethylamine-functionalized spiropyran (SP1).
Investigation of metal-sensing properties using UV-vis spectrophotometry.
Evaluation of selectivity against various biologically and environmentally relevant metal ions.

Main Results:

SP1 exhibits a visible color change upon complexation with Cu2+ at low micromolar concentrations (≈6 μM).
The limit of detection for Cu2+ using UV-vis spectrometry was determined to be 0.11 μM.
SP1 demonstrated high selectivity for Cu2+ over other common metal ions, with a linear response in the 0-20 μM range.

Conclusions:

SP1 serves as an effective colorimetric sensor for Cu2+ detection.
The sensor's sensitivity and selectivity make it promising for field testing of trace copper.
This development addresses the need for accessible and sensitive metal detection methods.