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639
Electrospun Chitosan-based Fibers for Wound Healing Applications
Sameer Sapkota1, Shih-Feng Chou1
1Department of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, Tyler, Texas, USA.
Journal of Biomaterials
|May 31, 2021
Summary
Electrospun chitosan fiber mats, blended with PEO or PVA, show promise as advanced wound dressings. These materials offer enhanced mechanical strength, porosity, and drug delivery capabilities for improved wound healing.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Tissue Engineering
Background:
- Chitosan is a biocompatible biopolymer with inherent antibacterial and hemostatic properties, making it suitable for wound dressings.
- Electrospinning of chitosan with water-soluble copolymers like polyethylene oxide (PEO) and polyvinyl alcohol (PVA) facilitates fiber formation.
- The resulting nonwoven fiber mats possess nano-sized diameters and porous structures.
Purpose of the Study:
- To review electrospun fiber-based wound dressings composed of chitosan and/or PEO and/or PVA.
- To highlight the structural and mechanical properties influenced by chitosan content.
- To discuss the potential for incorporating therapeutic agents for multi-purpose wound treatment.
Main Methods:
- Review of literature on electrospun chitosan, PEO, and PVA fiber blends for wound dressings.
- Analysis of fiber morphology, mechanical properties, and porosity.
- Discussion of antibacterial, anti-inflammatory, and drug delivery aspects.
Main Results:
- Incorporation of PEO/PVA enables continuous electrospinning of chitosan into nano-fibers.
- Increased chitosan content enhances the mechanical strength of the fiber mats.
- Nano-porous structure of the dressings improves permeability, exudate absorption, and reduces infection risk.
Conclusions:
- Electrospun chitosan-based fiber mats are effective wound dressing candidates due to their tunable properties.
- The porous structure and biocompatibility support wound healing by facilitating nutrient exchange and managing exudates.
- These dressings offer a versatile platform for delivering drugs and biological agents for comprehensive wound management.
