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Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
Published on: June 9, 2023
Effects of propolis and its bioactive components on breast cancer cell pathways and the molecular mechanisms involved
Rina Masadah1, Dzul Ikram1,2, Syahrul Rauf3
1Department of Pathology Anatomy, Hasanuddin University, Makassar, Indonesia.
Background:
Breast cancer is a female malignancy that is a significant cause of mortality worldwide. Currently, investigations on natural ingredients as new candidates for chemopreventive agents and breast cancer chemotherapies are increasing. Propolis is a natural resinous material produced by honeybees that exhibit anticancer potential. Several studies have mentioned the major bioactive compounds of propolis, but their mechanism of action is not clearly understood.
Objectives:
The purpose of this review is to collect and summarize the evidence related to the effectiveness of propolis and its bioactive contents as candidates for breast cancer therapy and analyze the molecular mechanisms involved in their therapeutic pathways.
Methods:
We reviewed 94 articles from journals and databases, extracted the results, and produced summaries and conclusions.
Results:
Propolis and its bioactive ingredients show cytotoxic, anti-proliferative, pro-autophagic, anti-metastatic, and antioxidant activities, as well as synergistic effects with chemotherapy or radiotherapy in breast cancer. Its therapeutic activity involves various target molecules, including NF-κβ, Fas receptors, p53, TLR4, ANXA7, and voltage-gated Na+ channel (VGSC).
Conclusion:
The bioactive components of propolis and the target molecules involved need to be explored further to develop new breast cancer therapies and overcome the problem of chemoradiation resistance.
Insights
Propolis, a natural bee product, shows significant potential in breast cancer treatment by exhibiting anticancer properties and enhancing chemotherapy. Further research into its bioactive compounds and molecular targets is crucial for developing novel therapies.
Area of Science:
- Natural Products Research
- Oncology
- Pharmacology
Background:
- Breast cancer remains a leading cause of mortality in women globally.
- Research into natural compounds for cancer prevention and treatment is expanding.
- Propolis, a bee-derived resin, possesses demonstrated anticancer properties, though its mechanisms require elucidation.
Purpose of the Study:
- To review and synthesize evidence on propolis and its constituents for breast cancer therapy.
- To analyze the molecular mechanisms underlying propolis's therapeutic effects in breast cancer.
Main Methods:
- A comprehensive literature review of 94 articles from scientific journals and databases.
- Extraction and summarization of findings related to propolis's efficacy and mechanisms in breast cancer.
Main Results:
- Propolis and its compounds exhibit cytotoxic, anti-proliferative, pro-autophagic, anti-metastatic, and antioxidant activities against breast cancer.
- Synergistic effects observed with conventional chemotherapy and radiotherapy.
- Therapeutic actions involve key molecular targets such as NF-κβ, Fas receptors, p53, TLR4, ANXA7, and voltage-gated sodium channels (VGSCs).
Conclusions:
- Further investigation of propolis's bioactive components and their molecular targets is essential.
- Developing novel breast cancer therapies based on propolis may help overcome chemoradiation resistance.
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