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Grapiprant: A snapshot of the current knowledge.

Irene Sartini1, Mario Giorgi2,3

  • 1Department of Veterinary Medicine, University of Sassari, Sassari, Italy.

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|May 31, 2021
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Summary

Grapiprant, a novel piprant drug, effectively manages pain and inflammation in dogs. Analytical methods are reliable, but pharmacokinetics vary by species, with efficacy better for chronic pain.

Keywords:
analytical methodgrapiprantpharmacodynamicspharmacokineticsreviewsafety

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Area of Science:

  • Veterinary Pharmacology
  • Drug Discovery
  • Animal Health

Background:

  • Grapiprant is a prostaglandin E2 receptor 4 antagonist.
  • It is approved for canine osteoarthritis pain and inflammation.

Purpose of the Study:

  • To review analytical methods, pharmacokinetics, pharmacodynamics, and safety of grapiprant in animals.
  • To synthesize evidence on grapiprant's use in veterinary medicine.

Main Methods:

  • Narrative review of published scientific evidence.
  • Analysis of data on analytical methods, pharmacokinetics, pharmacodynamics, and safety.

Main Results:

  • Analytical methods for grapiprant are validated, sensitive, and reliable.
  • Pharmacokinetics of grapiprant differ across animal species.
  • Grapiprant demonstrates greater efficacy for chronic pain compared to acute pain.

Conclusions:

  • Grapiprant is a well-characterized drug with reliable detection methods.
  • Species-specific pharmacokinetic data are crucial for dosing.
  • Its therapeutic application is more suitable for chronic pain management in animals.