Related Experiment Video
Updated: Nov 4, 2025
Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates
Published on: February 17, 2023
Profile and Epidemiology of Intussusception in Children Under-Two Years of Age: A Prospective Surveillance
Manoja Kumar Das1, Narendra Kumar Arora2, John Mathai3
1The INCLEN Trust International, F1/5, Okhla Industrial Area, Phase 1, New Delhi, 110020, India. manoj@inclentrust.org.
Insights
Intussusception commonly affects infants under two years old, with symptoms like vomiting and abdominal pain. This study establishes baseline epidemiology before rotavirus vaccine (RVV) introduction in India.
Area of Science:
- Pediatric Gastroenterology
- Epidemiology
- Vaccinology
Background:
- Intussusception is a significant cause of intestinal obstruction in infants globally.
- Understanding baseline epidemiology is crucial for assessing the impact of interventions like the rotavirus vaccine (RVV).
Purpose of the Study:
- To document the epidemiology of intussusception in children under two years old in Coimbatore, India.
- To establish pre-vaccination incidence rates for intussusception prior to rotavirus vaccine introduction.
Main Methods:
- Prospective sentinel surveillance was conducted in four hospitals over 18 months (April 2016-September 2017).
- Infants and young children (1-23 months) diagnosed with intussusception were recruited.
- Data collected included clinical presentation, treatment, diet, immunization status, and sociodemographics.
Main Results:
- Sixty-eight cases of intussusception were identified, predominantly in male infants aged 4-8 months.
- Common symptoms included vomiting (83.8%), abdominal pain (72.1%), and bloody stools (45.6%).
- Hospitalization incidence was estimated at 36.4 and 11.7 cases per 100,000 children/year in the first and second surveillance years, respectively. Only 24.1% had received any RVV dose.
Conclusions:
- Intussusception occurs in infants irrespective of rotavirus vaccine (RVV) exposure.
- Continued surveillance is essential to monitor epidemiological shifts post-RVV introduction.
Objective:
To report background intussusception epidemiology in children under-two years in Coimbatore district of Tamil Nadu state, India, prior to rotavirus vaccine (RVV) introduction.
Methods:
Prospective sentinel surveillance was done at four hospitals in Coimbatore during April 2016 to September 2017. The children aged >1 mo and < 24 mo with diagnosed intussusception were recruited and data on clinical, treatment, diet, immunization, and sociodemography were collected.
Results:
Sixty-eight children with intussusception were recruited. Among them 76.5% were infants with male predominance (57.4%) and 48.5% were 4-8 mo old. Vomiting (83.8%), pain in abdomen (including excessive crying) (72.1%), and bloody stools (45.6%) were the main symptoms. Reduction was tried in 92.6% cases with success in 83.8%. Surgery was needed by 16.2% children. No child died. Any RVV dose was received by 24.1% children and 2 children received RVV in 8-21 d and none within 1-7 d window. The incidence of intussusception requiring hospitalization was estimated to be 36.4 and 11.7 cases/100,000 children/y for the first and second years, respectively.
Conclusion:
Intussusception occurred in infants even without RVV exposure. Continued surveillance is needed to document the changes in intussusception epidemiology after RVV introduction.
Related Concept Videos
01:26Esophageal Strictures-II: Clinical Features and Management
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
01:08Prevalence and Incidence
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
01:30Esophageal Strictures-I: Introduction
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
01:28Esophageal Perforation-II: Clinical Manifestations and Management
Clinical Manifestations:
01:23Anatomy of the Intestines
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...