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Long non-coding RNA H19: Physiological functions and involvements in central nervous system disorders
Liyuan Zhong1, Ping Liu1, Junfen Fan1
1Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
Neurochemistry International
|May 31, 2021
Summary
Long non-coding RNA H19 (lncRNA H19) is crucial for central nervous system (CNS) development and homeostasis. Research shows lncRNA H19 is involved in the pathogenesis and treatment of CNS disorders, acting as a potential biomarker.
Area of Science:
- Neuroscience
- Molecular Biology
- Genetics
Background:
- Central nervous system (CNS) disorders present complex challenges due to the CNS's intricate structure.
- Long non-coding RNA H19 (lncRNA H19), once dismissed as transcriptional noise, is now recognized for its vital role in CNS development and homeostasis.
Purpose of the Study:
- To review the diverse functions and underlying mechanisms of lncRNA H19 in various CNS disorders.
- To explore lncRNA H19's potential as a biomarker and therapeutic target for CNS diseases.
Main Methods:
- Literature review of recent studies on lncRNA H19 and CNS disorders.
- Analysis of lncRNA H19's role in regulating transcription, translation, and signaling pathways.
Main Results:
- LncRNA H19 is implicated in the susceptibility and pathogenesis of CNS disorders including stroke, glioma, and neuroblastoma.
- It influences conditions such as Alzheimer's disease, Parkinson's disease, and epilepsy.
- LncRNA H19's regulatory functions highlight its significance in CNS disease mechanisms.
Conclusions:
- LncRNA H19 is a key player in the development and progression of CNS disorders.
- It represents a promising avenue for novel diagnostic and therapeutic strategies in neurology.
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