Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Association Areas of the Cortex

Association Areas of the Cortex

Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...

Long-Term Memory

Long-Term Memory

Long-term memory is a relatively permanent type of memory, capable of storing vast amounts of information over extended periods. Its storage capacity is generally considered unlimited.
Long-term memory can be categorized into two primary types: explicit and implicit memory. Explicit memory, also known as declarative memory, involves the conscious recollection of information that we deliberately try to remember, recall, and articulate. This type of memory encompasses specific facts, events, and...

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Personality factors associated with alcohol, tobacco and marijuana use in adolescents: A longitudinal study.

Adicciones·2026

Same author

Modeling microbiota-mediated risk for alcohol use disorder: a preclinical study of fecal transplantation from ethanol-exposed mice.

The American journal of drug and alcohol abuse·2026

Same author

The Predominant Role of Musical Valence Over Arousal in Pain Modulation: A Psychophysiological Study.

International journal of psychology : Journal international de psychologie·2025

Same author

Prenatal serotonin depletion persistently disrupts social behavior and modulates ΔFosB and SERT expression in mice.

Pharmacology, biochemistry, and behavior·2025

Same author

Could early-life stress block the promoting effect of adolescent ethanol exposure on later ethanol use?

Alcohol, clinical & experimental research·2025

Same author

Analysis of the synergy between prenatal ethanol and postnatal adolescent ethanol exposure.

Alcohol (Fayetteville, N.Y.)·2025

Search research articles

Related Experiment Video

Updated: Nov 4, 2025

A Behavioral Assay for Investigating the Role of Spatial Memory During Instinctive Defense in Mice

A Behavioral Assay for Investigating the Role of Spatial Memory During Instinctive Defense in Mice

Published on: July 21, 2018

Open field exposure facilitates the expression of a spatial, recognition memory.

Nadia Justel¹, Agustín Salguero², Leonardo Marengo²

¹Laboratorio de Psicología Experimental y Aplicada (PSEA), Instituto de Investigaciones Médicas (IDIM), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad de Buenos Aires (UBA), Argentina.

Neuroscience Letters

|May 31, 2021

Summary

Novelty exposure enhances spatial recognition memory in rats, even when cognitive function is impaired by scopolamine. This brief, non-pharmacological intervention improves memory expression.

Keywords:

Novelty exposure Open field Rat T maze

More Related Videos

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

Published on: January 26, 2024

Place and Response Learning in the Open-field Tower Maze

Place and Response Learning in the Open-field Tower Maze

Published on: October 28, 2015

Related Experiment Videos

Last Updated: Nov 4, 2025

A Behavioral Assay for Investigating the Role of Spatial Memory During Instinctive Defense in Mice

A Behavioral Assay for Investigating the Role of Spatial Memory During Instinctive Defense in Mice

Published on: July 21, 2018

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

Published on: January 26, 2024

Place and Response Learning in the Open-field Tower Maze

Place and Response Learning in the Open-field Tower Maze

Published on: October 28, 2015

Area of Science:

Neuroscience
Cognitive Psychology
Animal Behavior

Background:

Novelty influences aversive memory and frustration but its effect on non-emotional memories is less understood.
Spatial recognition memory is crucial for navigation and learning.

Purpose of the Study:

To investigate how brief novelty exposure affects spatial recognition memory expression in rats.
To determine if novelty exposure can counteract memory impairment induced by scopolamine.

Main Methods:

Rats were trained in a T-maze task to assess spatial recognition memory.
Scopolamine was administered to impair cholinergic function and memory.
Exposure to a novel open field environment was used as the novelty treatment.
Memory expression was tested at different time intervals (2h and 6h) and with different novelty exposure timings (pre-training and post-training).

Main Results:

Rats showed preference for the novel arm in the T-maze 2 hours after training, indicating spatial recognition memory.
Scopolamine impaired this recognition memory.
Post-training novelty exposure rescued the scopolamine-induced memory impairment.
Pre-training novelty exposure improved memory expression, even with a 6-hour delay and despite cholinergic blockade.

Conclusions:

A brief exposure to novelty can significantly enhance the expression of spatial recognition memory.
Novelty exposure serves as an effective non-pharmacological strategy to modulate memory, potentially overcoming cognitive deficits.
These findings suggest novelty as a therapeutic avenue for memory-related disorders.