Stimulus-responsive liposomes for biomedical applications.
Antonia I Antoniou1, Sabrina Giofrè1, Pierfausto Seneci1
1Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, Milano 20133, Italy.
Drug Discovery Today
|May 31, 2021
Summary
Chemically modified liposomes offer advanced drug delivery. These smart systems enhance targeting and responsiveness for improved therapeutic outcomes.
Area of Science:
- Nanotechnology and Materials Science
- Pharmaceutical Sciences
- Biochemistry
Background:
- Liposomes are versatile lipid-based nanoparticles for encapsulating diverse molecules.
- Established use in drug delivery due to biocompatibility, biodegradability, and low toxicity.
- Existing liposomes offer synthetic flexibility for various applications.
Purpose of the Study:
- To review chemical modifications enhancing liposome functionality.
- To focus on stimuli-responsive and prodrug-activating liposome systems.
- To highlight advancements in smart liposome-based drug delivery.
Main Methods:
- Review of existing literature on liposome chemical modifications.
- Analysis of internal stimuli-responsive mechanisms.
- Examination of prodrug activation strategies within liposomes.
Main Results:
- Chemical modifications enable tunable and disease-directed liposome features.
- Internal stimuli-responsive liposomes show promise for targeted drug release.
- Prodrug activation strategies integrated into liposomes enhance therapeutic efficacy.
Conclusions:
- Chemical modification is key to developing advanced liposome drug delivery systems.
- Smart liposomes offer improved control over drug release and targeting.
- Future research directions include further optimization of stimuli-responsive and prodrug systems.
