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An empirical artifact correction for proton computed tomography.

Jannis Dickmann1, Christina Sarosiek2, Stefanie Götz1

  • 1Department of Medical Physics, Fakultät für Physik, Ludwig-Maximilians-Universität München (LMU Munich), Am Coulombwall 1, Garching bei München, Germany.

Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)
|May 31, 2021
PubMed
Summary

A new empirical method significantly reduced image artifacts in preclinical proton computed tomography (pCT) scans. This improves the accuracy of relative stopping power (RSP) imaging for particle therapy planning.

Keywords:
Artifact reductionImage qualityParticle therapyProton computed tomography

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Area of Science:

  • Medical Physics
  • Radiological Imaging
  • Particle Therapy

Background:

  • Proton computed tomography (pCT) is crucial for accurate particle therapy planning.
  • Image artifacts in pCT can compromise the precision of relative stopping power (RSP) determination.
  • Existing methods may not fully address artifacts in preclinical pCT systems.

Purpose of the Study:

  • To reduce image artifacts in preclinical proton computed tomography (pCT).
  • To improve the accuracy of relative stopping power (RSP) imaging for particle therapy treatment planning.
  • To implement a simple empirical artifact correction method.

Main Methods:

  • Adapted a beam-hardening correction method from x-ray CT for pCT.
  • Utilized a homogeneous phantom with known RSP for calibration.
  • Applied a derived correction function to experimental pCT scans of various phantoms.

Main Results:

  • Significantly reduced ring artifacts and offset errors in pCT images.
  • Lowered the mean absolute percentage error (MAPE) of RSP values from ~0.87% to ~0.44% in phantoms.
  • Observed clear artifact reduction in an anthropomorphic head phantom.

Conclusions:

  • The empirical correction method substantially reduces artifacts in preclinical pCT.
  • Improved RSP accuracy was achieved across homogeneous, heterogeneous, and anthropomorphic phantoms.
  • This method enhances the utility of pCT for particle therapy applications.