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Related Concept Videos

Genomics02:02

Genomics

38.3K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Genome Annotation and Assembly03:36

Genome Annotation and Assembly

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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Evolutionary Relationships through Genome Comparisons02:54

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Genome Size and the Evolution of New Genes03:21

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Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

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While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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Development and Validation of a Comprehensive Genomics Knowledge Scale.

Michael D Linderman1, Sabrina A Suckiel2, Nathan Thompson3

  • 1Department of Computer Science, Middlebury College, Middlebury, Vermont, USA.

Public Health Genomics
|May 31, 2021
PubMed
Summary
This summary is machine-generated.

A new 26-item GKnowM scale accurately measures genomics knowledge for informed decisions and effective education. This tool is crucial for assessing population genomic literacy and the impact of educational programs.

Keywords:
Computerized adaptive testingGenomic literacyGenomic sequencingInformed decision-makingKnowledge measure

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Area of Science:

  • Genomics
  • Psychometrics
  • Health Literacy

Background:

  • Genomic testing is widespread across clinical, research, and commercial sectors.
  • Genomic literacy is essential for the effective use of genomic testing.
  • Validated tools are needed to assess genomics knowledge in diverse populations.

Purpose of the Study:

  • To develop and validate the GKnowM Genomics Knowledge Scale.
  • To create a reliable measure for informed decision-making regarding genomic testing.
  • To assess knowledge relevant to genomic technologies and civic engagement.

Main Methods:

  • Developed a 30-item draft scale, administered to 2,405 participants.
  • Performed psychometric calibration and validation using classical test theory and IRT.
  • Evaluated suitability for computerized adaptive testing (CAT).

Main Results:

  • The final 26-item GKnowM scale demonstrated strong internal consistency (α = 0.85).
  • The scale showed good validity, correlating with existing measures and differentiating knowledge levels.
  • The item bank is suitable for CAT, reducing the number of items administered.

Conclusions:

  • GKnowM is a validated, broadly relevant measure for assessing genomics knowledge.
  • The scale can evaluate population genomic literacy and educational intervention effectiveness.
  • GKnowM supports informed decision-making and participation in genomic healthcare.