Related Experiment Video
Updated: Nov 3, 2025

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
Antitumor activity of tridentate pincer and related metal complexes
Shulei Wu1, Zaoduan Wu1, Qianyi Ge1
1Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pharmacy & Pharmacology, Affiliated Nanhua Hospital, University of South China, 28 Western Changsheng Road, Hengyang 421001, Hunan, PR China. yangzehua@usc.edu.cn zhengxing9166@sohu.com.
Abstract:
Pincer complexes featuring tunable tridentate ligand frameworks are one of the most actively studied classes of metal-based complexes. Currently, growing attention is devoted to the cytotoxicity of pincer and related metal complexes. The antiproliferative activity of numerous pincer complexes has been reported. Pincer tridentate ligand scaffolds show different coordination modes and offer multiple options for directed structural modifications. This review summarizes the significant progress in the research studies of the antitumor activity of pincer and related platinum(ii), gold(iii), palladium(ii), copper(ii), iron(iii), ruthenium(ii), nickel(ii) and some other metal complexes, in order to provide a reference for designing novel metal coordination drug candidates with promising antitumor activity.
Related Concept Videos
EDTA: Chemistry and Properties
Complexation Equilibria: The Chelate Effect
Metal-Ligand Bonds
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Valence Bond Theory
Complexometric Titration: Ligands
Coordination Number and Geometry

