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Future surgical innovations aim to improve breast cancer management by reducing treatment side effects and enhancing surgical precision. Advances in technology and understanding tumor biology are enabling more personalized and effective breast cancer care.

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Area of Science:

  • Surgical Oncology
  • Breast Cancer Management
  • Medical Technology

Background:

  • Discusses future innovations in science and technology impacting multimodal breast cancer management.
  • Focuses on the surgical perspective in response to the Royal College of Surgeons of England's Future of Surgery project.

Purpose of the Study:

  • To review expert opinions on surgical de-escalation and reducing treatment morbidities.
  • To explore improvements in breast-conserving surgery accuracy and margin assessment.
  • To examine the evolving role of surgery alongside systemic therapies and oncoplastic approaches.

Main Methods:

  • Gathered expert opinions on key themes in breast cancer surgery.
  • Reviewed current and emerging technologies for surgical management.
  • Analyzed the impact of systemic therapies and genomic profiling on surgical decisions.

Main Results:

  • Intraoperative margin assessment technologies may halve re-excision rates.
  • Sentinel lymph node biopsy is evolving into a therapeutic procedure.
  • Genomic profiling aids in selecting patients for tailored therapies and prevention strategies.

Conclusions:

  • Treatment tailoring based on tumor biology and biomarkers improves outcomes and cost-effectiveness.
  • Patient involvement is crucial for relevant and patient-centered breast cancer research.
  • Response-adapted approaches in breast and axillary surgery are becoming more prevalent.