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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Structural Joints: Synovial Joints01:16

Structural Joints: Synovial Joints

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Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
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Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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Related Experiment Video

Updated: Nov 3, 2025

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

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Psoriatic arthritis.

Yoshinori Umezawa1

  • 1Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.

The Journal of Dermatology
|June 1, 2021
PubMed
Summary

Psoriatic arthritis (PsA) is a chronic inflammatory condition affecting joints and potentially causing bone destruction. Early diagnosis and treatment are crucial for managing PsA and improving patient quality of life.

Area of Science:

  • Rheumatology
  • Dermatology
  • Immunology

Background:

  • Psoriatic arthritis (PsA) is a chronic inflammatory condition linked to psoriasis, affecting approximately 10% of psoriatic patients in Japan.
  • PsA commonly impacts peripheral joints, the spine, and sacroiliac joints, potentially leading to irreversible bone destruction and joint dysfunction if untreated.

Purpose of the Study:

  • To highlight the importance of early detection and treatment in managing psoriatic arthritis.
  • To discuss the diagnostic challenges and available therapeutic strategies for PsA.

Main Methods:

  • Review of current understanding of PsA pathology and treatment landscape.
  • Discussion of diagnostic tools including imaging (MRI, ultrasound) and questionnaires for challenging cases.
  • Overview of therapeutic options: NSAIDs, DMARDs, and biologics.
Keywords:
biologicsguidelinespsoriasispsoriatic arthritisquality of llife

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Main Results:

  • PsA diagnosis can be challenging due to delayed radiographic findings or normal inflammatory markers in early stages.
  • Advanced imaging and symptom questionnaires aid in diagnosing PsA when traditional markers are inconclusive.
  • Current treatments, including biologics, offer improved outcomes when employed aggressively.

Conclusions:

  • Early and aggressive management of psoriatic arthritis is essential for preventing joint damage and preserving patient quality of life.
  • A multi-faceted approach combining pharmacotherapy and advanced diagnostics is key to effective PsA treatment.