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Physical and psychological sequelae at three months after acute illness in COVID-19 survivors

Rebecca DE Lorenzo1, Elena Cinel1, Marta Cilla1

  • 1Vita-Salute San Raffaele University, Milan, Italy.

Panminerva Medica
|June 1, 2021
PubMed

Insights

Many COVID-19 survivors experience persistent health issues three months post-discharge, including respiratory dysfunction and mental health challenges. Ongoing follow-up care is crucial for managing long-term effects of coronavirus disease 2019.

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Psychiatry

Background:

  • Coronavirus disease 2019 (COVID-19) can lead to prolonged health issues post-recovery.
  • Assessing the clinical status of COVID-19 survivors at three months after hospital discharge is important for understanding long-term impacts.

Purpose of the Study:

  • To evaluate the clinical status of COVID-19 survivors at three months post-hospital discharge.
  • To identify predictors of residual respiratory dysfunction and mental health conditions in COVID-19 survivors.

Main Methods:

  • A prospective observational cohort study included 251 hospitalized COVID-19 patients (age ≥18).
  • Patients were evaluated at one month (M1) and three months (M3) post-discharge.
  • Primary outcome was residual respiratory dysfunction (RRD), defined by specific respiratory symptoms and oxygen saturation.

Main Results:

  • Residual respiratory dysfunction (RRD) was present in 30.4% of patients at M3, with no significant change from M1.
  • Chronic obstructive pulmonary disease and longer hospital stays predicted RRD.
  • Over 50% reported impaired quality of life, and significant proportions experienced anxiety, insomnia, and PTSD, with insomnia decreasing by M3.

Conclusions:

  • Clinical sequelae of COVID-19 can persist three months after hospital discharge.
  • Post-recovery follow-up is essential for managing the long-term health of COVID-19 survivors.
Abstract

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