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Published on: January 4, 2018
Pentafluoroethylation of Carbonyl Compounds Using HFC-125 in a Flow Microreactor System
Makoto Ono1, Yuji Sumii1, Yamato Fujihira1
1Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso, Showa-Ku, Nagoya 466-8555, Japan.
Abstract:
The protocol of micro-flow nucleophilic pentafluoroethylation using pentafluoroethane (HC2F5, HFC-125), a nontoxic, inexpensive, and commercially available greenhouse gas, is described. The micro-flow pentafluoroethylation by HFC-125 proceeded smoothly at room temperature or at -10 °C in DMF or toluene in the presence of a potassium base, namely, t-BuOK or KHMDS. A broad range of ketones, aldehydes, and chalcones with various substituted benzene rings were successfully converted to the corresponding pentafluoroethyl carbinols instantly with good to high yields.

