Reducing Constipation-Related Admissions: The Effectiveness of Antegrade Continence Enema Procedures in Children

Joseph R Esparaz1,2, Alicia M Waters1,2, Michelle S Mathis1

  • 1Division of Pediatric Surgery, 22078Children's of Alabama, Birmingham, AL, USA.

Insights

Antegrade continence enema (ACE) procedures significantly reduced hospital admissions for pediatric constipation. This approach improves symptoms and decreases patient distress, allowing for effective outpatient management.

Area of Science:

  • Pediatric Gastroenterology
  • Surgical Interventions for Functional Bowel Disorders

Background:

  • Pediatric constipation is a prevalent issue.
  • Antegrade continence enema (ACE) procedures alleviate daily therapy distress.
  • ACE enables more effective outpatient management of constipation.

Purpose of the Study:

  • To evaluate the impact of ACE procedures on hospital admissions for pediatric constipation.
  • To test the hypothesis that ACE procedures reduce constipation-related hospitalizations.

Main Methods:

  • Retrospective analysis of 48 pediatric patients who underwent ACE procedures (2015-2018).
  • Analysis of demographics, diagnoses, procedure types, and pre/postoperative hospital admissions.
  • Focus on appendicostomy as the primary ACE procedure.

Main Results:

  • Preoperatively, 26 patients had 63 admissions for constipation.
  • Postoperatively, only 4 patients had 5 admissions (P = .021).
  • 28 patients required non-scheduled appendicostomy tube replacement.

Conclusions:

  • ACE procedures significantly decrease hospital admissions for pediatric constipation.
  • ACE is an effective intervention for improving constipation-related symptoms in children.
  • Outpatient ACE management can lead to fewer hospitalizations.
Abstract

Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
426
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
389
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
252
Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
656
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives

Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
371
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents01:20

Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents

Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
410