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[Tardive akathisia after long-term metoclopramide treatment]

Astrid Johannesson Hjelholt1, Charlotte Uggerhøj Andersen, Charlotte Steffensen

  • 1ajh@clin.au.dkk.

Ugeskrift for Laeger
|June 1, 2021
PubMed

Insights

Long-term metoclopramide use can cause tardive akathisia, a movement disorder characterized by inner restlessness. Healthcare providers should limit treatment duration and monitor for neurological side effects.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Metoclopramide, a dopamine receptor antagonist, is frequently used for gastrointestinal disorders.
  • Drug-induced movement disorders are a known class of adverse effects associated with dopamine receptor antagonists.

Observation:

  • A 57-year-old male presented with symptoms suggestive of tardive akathisia.
  • The patient had a history of long-term metoclopramide treatment.

Findings:

  • The case report links prolonged metoclopramide exposure to the development of tardive akathisia.
  • Tardive akathisia is distinguished from acute akathisia by its delayed onset after extended medication use and potential permanence.

Implications:

  • Restricting the duration of metoclopramide treatment is crucial to mitigate the risk of developing tardive akathisia.
  • Increased clinical awareness of metoclopramide's potential neurological side effects, particularly movement disorders, is warranted.

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