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Related Experiment Videos

Bipolar patients taking lithium have increased dark adaptation threshold compared with controls.

P A Carney1, J Seggie, M Vojtechovsky

  • 1Dept. of Psychiatry, McMaster University, Hamilton, Ontario, Canada.

Pharmacopsychiatry
|May 1, 1988
PubMed
Summary

Lithium treatment may alter light sensitivity in patients with manic-depressive illness. This study found that lithium intake significantly raised the dark adaptation threshold, indicating reduced light sensitivity.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Chronobiology

Background:

  • Epidemiological studies link mania admissions to sunlight exposure.
  • Seasonal Affective Disorder (SAD) responds to light therapy.
  • Supersensitivity to light is proposed as a trait marker for manic-depressive illness.

Purpose of the Study:

  • To investigate the effect of lithium on light sensitivity in euthymic patients with manic-depressive illness.
  • To compare light sensitivity between patients on lithium and healthy controls.

Main Methods:

  • Assessed Dark Adaptation Threshold (D.A.T.), a measure of night vision.
  • Studied 19 euthymic manic-depressive patients stabilized on lithium.
  • Included 19 drug-free healthy controls for comparison.

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Main Results:

  • The Dark Adaptation Threshold (D.A.T.) was significantly elevated in patients receiving lithium.
  • This indicates a reduced sensitivity to light in the patient group.

Conclusions:

  • Lithium treatment appears to induce subsensitivity to light in individuals with manic-depressive illness.
  • Findings suggest a potential mechanism linking lithium's therapeutic effects to light perception.