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Updated: Nov 3, 2025

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells
Published on: January 5, 2024
New insights into promoter-enhancer communication mechanisms revealed by dynamic single-molecule imaging
Jieru Li1, Alexandros Pertsinidis1
1Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, U.S.A.
Abstract:
Establishing cell-type-specific gene expression programs relies on the action of distal enhancers, cis-regulatory elements that can activate target genes over large genomic distances - up to Mega-bases away. How distal enhancers physically relay regulatory information to target promoters has remained a mystery. Here, we review the latest developments and insights into promoter-enhancer communication mechanisms revealed by live-cell, real-time single-molecule imaging approaches.
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