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Updated: Nov 3, 2025
09:15
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
14.8K
Inclisiran in dyslipidemia
C E Kosmas1, A Muñoz Estrella2, A Sourlas3
1Division of Cardiology, Department of Medicine, Montefiore Medical Center, Bronx, New York City, New York, USA. cekosmas1@gmail.com.
Drugs of Today (Barcelona, Spain : 1998)
|June 1, 2021
Summary
Inclisiran, a novel siRNA therapy, offers a new approach to managing hypercholesterolemia for patients unresponsive or intolerant to statins. It effectively lowers LDL-C by targeting PCSK9 transcription, providing a promising alternative for cardiovascular disease risk reduction.
Area of Science:
- Cardiovascular Medicine
- Pharmacology
- RNA Therapeutics
Background:
- Cardiovascular disease (CVD) remains a leading global cause of mortality.
- Hypercholesterolemia is a primary risk factor for CVD.
- Statins are standard treatment but have limitations including efficacy and side effects.
Purpose of the Study:
- To review the role of inclisiran in managing hypercholesterolemia.
- To highlight inclisiran as a novel therapeutic agent for lipid management.
Main Methods:
- Review of scientific literature on inclisiran and hypercholesterolemia management.
- Focus on the mechanism of action of inclisiran as a small interfering RNA (siRNA).
Main Results:
- Inclisiran reduces LDL-C by inhibiting PCSK9 transcription, increasing LDL receptor recycling.
- It offers an alternative for patients with statin intolerance or suboptimal response.
- Received EU marketing authorization in December 2020.
Conclusions:
- Inclisiran represents a significant advancement in hypercholesterolemia treatment.
- Its unique mechanism provides a new option for reducing cardiovascular risk.
- Further research and clinical application are expected.
Keywords:
Cardiovascular diseaseHypercholesterolemiaInclisiranMetabolic diseasesProprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitorsSmall interfering RNA (siRNA) moleculesTreatment of lipoprotein disordersMore Related Videos
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