Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regression Toward the Mean01:52

Regression Toward the Mean

6.6K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.6K
Mitral Valve Prolapse III: Nursing Management01:19

Mitral Valve Prolapse III: Nursing Management

92
The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
92
Kaplan-Meier Approach01:24

Kaplan-Meier Approach

345
The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
345

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endometrial Microbiome Profiles in Women Evaluated for Infertility or Recurrent Miscarriage: A Single-Center Descriptive Study.

Diagnostics (Basel, Switzerland)·2026
Same author

Preconception and first-trimester metformin for improving pregnancy outcomes in women with polycystic ovary syndrome.

The Cochrane database of systematic reviews·2026
Same author

Do Not Treat a Sequencing Report: Therapeutic Stewardship in Endometrial Microbiome Testing.

American journal of therapeutics·2026
Same author

Miscarriage, self-harm, and psychiatric disorders in first-time pregnant women: Evidence from a linkage study.

Social science & medicine (1982)·2026
Same author

Blood Pressure Targets in Thoracic Aortic Disease: A Practical Comparison of ACC/AHA Guidance and Post-2024 European Guidelines.

American journal of therapeutics·2026
Same author

Prevention of postpartum haemorrhage: from evidence to implementation at scale.

Lancet (London, England)·2026

Related Experiment Video

Updated: Nov 3, 2025

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
05:16

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Published on: August 4, 2021

3.5K

Methods for managing miscarriage: a network meta-analysis.

Jay Ghosh1, Argyro Papadopoulou1, Adam J Devall1

  • 1Tommy's National Centre for Miscarriage Research, Institute of Metabolism and Systems Research (IMSR), WHO Collaborating Centre for Global Women's Health Research, University of Birmingham, Birmingham, UK.

The Cochrane Database of Systematic Reviews
|June 1, 2021
PubMed
Summary
This summary is machine-generated.

Surgical and medical interventions for early miscarriage are more effective than expectant management. Surgical methods ranked highest, followed by medical treatments, with expectant management having the highest risk of complications.

More Related Videos

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

841
Introduction of Intracapsular Rotary-cut Procedures IRCP: A Modified Hysteromyomectomy Procedures Facilitating Fertility Preservation
05:46

Introduction of Intracapsular Rotary-cut Procedures IRCP: A Modified Hysteromyomectomy Procedures Facilitating Fertility Preservation

Published on: January 17, 2019

10.2K

Related Experiment Videos

Last Updated: Nov 3, 2025

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
05:16

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Published on: August 4, 2021

3.5K
Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

841
Introduction of Intracapsular Rotary-cut Procedures IRCP: A Modified Hysteromyomectomy Procedures Facilitating Fertility Preservation
05:46

Introduction of Intracapsular Rotary-cut Procedures IRCP: A Modified Hysteromyomectomy Procedures Facilitating Fertility Preservation

Published on: January 17, 2019

10.2K

Area of Science:

  • Reproductive Health
  • Clinical Effectiveness Research
  • Evidence Synthesis

Background:

  • Miscarriage, a common pregnancy loss before 24 weeks, affects approximately 15% of pregnancies.
  • Early miscarriages (before 14 weeks) can be managed expectantly, medically, or surgically, but evidence on comparative effectiveness is limited.
  • Inadequate healthcare can increase miscarriage-related morbidity and mortality.

Purpose of the Study:

  • To compare the effectiveness and safety of different early miscarriage management methods.
  • To rank management options based on efficacy, safety, and side-effect profiles using network meta-analysis.

Main Methods:

  • Conducted a systematic search of randomized controlled trials (RCTs) for early miscarriage management.
  • Included 78 RCTs (17,795 women) comparing expectant management, medical treatments (misoprostol, mifepristone plus misoprostol), and surgical interventions (suction aspiration, dilatation and curettage).
  • Performed network meta-analysis to estimate relative effects and rankings for complete miscarriage and serious complications.

Main Results:

  • Surgical methods (suction aspiration, dilatation and curettage) and medical treatments (mifepristone plus misoprostol, misoprostol) were more effective than expectant management for achieving complete miscarriage.
  • Surgical methods were ranked highest, followed by medical methods, then expectant management.
  • No deaths were reported; however, expectant management had the highest risk of serious complications, such as blood transfusions and unplanned surgery.

Conclusions:

  • All evaluated surgical and medical methods for early miscarriage management are likely more effective than expectant management.
  • Surgical interventions demonstrate the highest effectiveness, followed by medical treatments.
  • Expectant management is associated with a higher likelihood of serious complications, including emergency surgery.