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Neuropsychological Sequelae of Coronary Heart Disease in Women: A Systematic Review
N F Narvaez Linares1, M Poitras1, J Burkauskas2
1Behavioural Neuroscience Group, School of Psychology, University of Ottawa, 136 Jean-Jacques Lussier, Ottawa, ON, K1N 6N5, Canada.
Insights
Coronary heart disease (CHD) survivors, particularly women, face risks of neurodegenerative diseases. This review highlights the need for more research on CHD
Area of Science:
- Cardiology
- Neurology
- Women's Health
Background:
- Coronary heart disease (CHD) is a leading cause of death in aging women, with increasing survival rates.
- Cardiovascular disease (CVD) is linked to neurodegenerative diseases, suggesting CHD may be a precursor.
- CVD research has historically underrepresented women, creating knowledge gaps.
Purpose of the Study:
- To conduct the first systematic review on the neuropsychological consequences of CHD specifically in women.
- To clarify the association between CHD and women's neuropsychological status.
- To identify research gaps and guide future studies.
Main Methods:
- Systematic review of existing literature.
- Analysis of neuropsychological sequelae in women with CHD.
- Assessment of research methodologies and variable definitions.
Main Results:
- Studies frequently include insufficient numbers of women.
- Inconsistent definitions of CHD complicate research findings.
- Evidence supports the heart-brain disease hypothesis in women.
Conclusions:
- Further research is crucial to understand CHD's impact on women's brain health.
- Standardized definitions and increased female participation in studies are recommended.
- Addressing these issues will improve understanding and care for women survivors of CHD.
Abstract:
Heart disease, such as coronary heart disease (CHD), is the leading cause of death among aging women. However, over the past years, the mortality rate has declined, resulting in an increased number of CHD survivors. In this context, research has uncovered relationships between cardiovascular disease (CVD) and the development of neurodegenerative diseases, suggesting that CHD can act as a precursor. Despite heart disease affecting both sexes, CVD research has significantly neglected women. Therefore, we conducted the first systematic review of neuropsychological sequelae of CHD in women to gain a clear portrait of the current knowledge of the association of CHD on women's neuropsychological status. We found that studies continue to include an insufficient number of women in their research. Our work also uncovered that there is variability in the definition of CHD by researchers (i.e., operationalization of the variable), which could explain inconsistencies across studies. Overall, we found evidence that supports the heart-brain disease hypothesis. To conclude, we provide several guidelines for future research involving the impact of CHD in women.
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