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Updated: Nov 3, 2025
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
Salmonella enterica subsp. enterica host-pathogen interactions and their implications in gallbladder cancer
Abdul Arif Khan1, Yasmin Bano2
1Indian Council of Medical Research-National AIDS Research Institute, Pune, Maharashtra, 411026, India.
Background:
Several studies have linked chronic typhoid infection with gallbladder carcinoma without completely understood mechanism. This study was performed in order to understand role of Salmonella in gallbladder cancer etiology.
Methods:
Known Salmonella host-pathogen interactions were screened from database in addition to known gallbladder carcinoma targets. Host-pathogen interaction map of S. enterica was prepared and screened for interactions with gallbladder carcinoma targets. Further functional overrepresentation analysis was performed to understand the role of human targets involved in Salmonella host-pathogen interactions in gallbladder carcinoma.
Results:
Salmonella interact with several human proteins involved in gallbladder carcinoma. MAPK and RAC1 are the most important human proteins based on node degree value among all GBC associated interactors identified in current data search. Functional over-representation analysis reveals that Salmonella can induce adenocarcinoma which constitutes 85% of gallbladder cancer.
Conclusion:
Though, the role of MAPK/ERK and PI3K/AKT/mTOR pathway is already suggested for Salmonella mediated gallbladder cancer, but current data based approach indicate several new insight for exploration of the role of Salmonella in gallbladder cancer etiology. The results indicate about several other processes including CREB/SP-1 and BSG(CD147) signaling, that must be given consideration for understanding the role of Salmonella in gallbladder cancer.
Insights
Chronic Salmonella infection is linked to gallbladder cancer. This study reveals Salmonella interacts with human proteins, potentially inducing adenocarcinoma and highlighting new signaling pathways involved in gallbladder cancer etiology.
Area of Science:
- Microbiology
- Oncology
- Bioinformatics
Background:
- Chronic typhoid infection, caused by Salmonella, is associated with gallbladder carcinoma.
- The precise mechanisms linking Salmonella to gallbladder cancer remain unclear.
Purpose of the Study:
- To elucidate the role of Salmonella in the etiology of gallbladder cancer.
- To identify specific host-pathogen interactions relevant to gallbladder cancer development.
Main Methods:
- Screening of Salmonella host-pathogen interactions and known gallbladder carcinoma targets from databases.
- Construction and analysis of a host-pathogen interaction map for S. enterica.
- Functional overrepresentation analysis to assess the role of human targets in gallbladder cancer.
Main Results:
- Salmonella interacts with multiple human proteins implicated in gallbladder carcinoma.
- MAPK and RAC1 were identified as key human proteins in Salmonella-associated gallbladder cancer.
- Functional analysis indicated Salmonella's potential to induce adenocarcinoma, the predominant form of gallbladder cancer.
Conclusions:
- This data-driven approach offers new insights beyond established pathways like MAPK/ERK and PI3K/AKT/mTOR.
- Identified novel pathways, including CREB/SP-1 and BSG(CD147) signaling, warrant further investigation.
- These findings contribute to a deeper understanding of Salmonella's role in gallbladder cancer pathogenesis.
