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Related Experiment Video

Updated: Nov 3, 2025

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
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Structural Endpoints and Outcome Measures in Uveitis.

Maximilian W M Wintergerst1, Xiaoxuan Liu2,3,4, Jan H Terheyden5

  • 1Department of Ophthalmology, University Hospital Bonn, Bonn, Germany, maximilian.wintergerst@ukbonn.de.

Ophthalmologica. Journal International D'Ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde
|June 1, 2021
PubMed
Summary
This summary is machine-generated.

Uveitis, a rare disease causing significant vision loss, needs standardized outcome measures for clinical trials. Optical coherence tomography and angiography are key for objective assessment.

Keywords:
BiomarkerEndpointImaging biomarkerInflammatory eye diseasesInstrument-based measureOutcomeOutcome measureUveitis

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Area of Science:

  • Ophthalmology
  • Clinical Trials
  • Rare Diseases

Background:

  • Uveitis causes 5-10% of global visual impairment, primarily affecting working-age individuals.
  • Clinical management of uveitis is hindered by a lack of high-level evidence and reliable quantitative endpoints for trials.

Purpose of the Study:

  • To review available structural outcome measures for assessing uveitis disease activity and damage.
  • To identify suitable endpoints for clinical uveitis trials and highlight core assessment modalities.

Main Methods:

  • Systematic review of structural outcome measures for uveitis.
  • Anatomical organization of measures from anterior to posterior eye segments.
  • Evaluation of modalities based on regulatory agency criteria for clinical trial endpoints.

Main Results:

  • Numerous structural outcome measures exist, but their suitability as clinical trial endpoints requires thorough validation.
  • Consensus on endpoint definition, standardization, and core outcomes is necessary.
  • Optical coherence tomography, fundus photography, fundus autofluorescence, and angiography are identified as core modalities.

Conclusions:

  • Standardization and validation of structural outcome measures are crucial for advancing uveitis clinical trials.
  • Selected imaging modalities offer reliable and objective quantification of uveitis outcomes.
  • Further research is needed to establish consensus on core outcome sets for uveitis research.