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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
143
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

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Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
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Rheumatic Heart Disease IV: Nursing Management01:20

Rheumatic Heart Disease IV: Nursing Management

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AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
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Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

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Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
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Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

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Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
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Related Experiment Video

Updated: Nov 3, 2025

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
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[Lung involvement in rheumatic diseases].

Hans Bastian1, Andreas Krause1

  • 1Abteilung Innere Medizin, Rheumatologie, Klinische Immunologie und Osteologie, Immanuel-Krankenhaus Berlin, Standort Berlin-Wannsee.

Deutsche Medizinische Wochenschrift (1946)
|June 1, 2021
PubMed
Summary
This summary is machine-generated.

Interstitial lung diseases (ILD) frequently affect patients with connective tissue diseases (CTD-ILD). Recent advances show methotrexate may not cause RA-lung disease, tocilizumab may help SSc-ILD, and nintedanib is approved for progressive fibrosing ILD.

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Area of Science:

  • Rheumatology
  • Pulmonology
  • Immunology

Background:

  • Connective tissue diseases (CTD) frequently manifest with lung involvement, termed CTD-ILD.
  • Rheumatoid arthritis (RA), systemic sclerosis (SSc), and idiopathic inflammatory myopathies are common CTDs associated with ILD.
  • Interstitial lung diseases (ILD) contribute significantly to morbidity and mortality in these patient populations.

Purpose of the Study:

  • To review recent advances in the management and treatment of ILDs in rheumatic diseases.
  • To evaluate the role of specific therapies like methotrexate, tocilizumab, and nintedanib in managing CTD-ILD.

Main Methods:

  • Literature review of recent studies on CTD-ILD treatments.
  • Analysis of treatment outcomes for methotrexate, tocilizumab, and nintedanib in specific ILD contexts.

Main Results:

  • Methotrexate is unlikely to be a significant cause of lung disease in RA and may even delay ILD onset.
  • Tocilizumab shows potential as a treatment for Systemic Sclerosis-ILD (SSc-ILD), though further research is needed.
  • Antifibrotic therapy with nintedanib is now an approved treatment for progressive fibrosing ILD and SSc-ILD.

Conclusions:

  • Advances in ILD management offer new therapeutic avenues for patients with rheumatic diseases.
  • Targeted therapies like tocilizumab and nintedanib represent significant progress in treating specific CTD-ILD subtypes.
  • Continued research is crucial to optimize treatment strategies and improve outcomes for CTD-ILD patients.