Related Experiment Video
Updated: Nov 3, 2025
07:46
Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration
Published on: June 18, 2018
12.2K
Environmental Risk Factors for Progressive Supranuclear Palsy
Hee Kyung Park1,2, Sindana D Ilango3,4, Irene Litvan5
1Department of Neurology, Ewha Womans Mokdong Hospital, Ewha Womans University, Seoul, Korea.
Journal of Movement Disorders
|June 1, 2021
Summary
Environmental factors like diet toxins, metals, and well water may increase progressive supranuclear palsy (PSP) risk. Higher education and statins might offer protection against this neurodegenerative disease.
Area of Science:
- Neuroscience
- Environmental Health
- Epidemiology
Background:
- Progressive supranuclear palsy (PSP) presents with characteristic motor and cognitive impairments.
- Recognized PSP phenotypes have expanded, leading to revised diagnostic criteria and increased prevalence estimates.
- Identifying modifiable risk factors is crucial for PSP intervention and prevention strategies.
Purpose of the Study:
- To review existing literature on environmental and lifestyle risk factors associated with progressive supranuscular palsy (PSP).
- To synthesize current evidence regarding factors that may increase or decrease PSP risk.
Main Methods:
- A comprehensive literature review was conducted.
- Studies investigating the relationship between PSP and environmental/lifestyle factors were analyzed.
Main Results:
- Exposure to dietary toxins, metals, well water, and hypertension were associated with increased PSP risk.
- Higher educational attainment and statin use showed potential protective effects against PSP.
- Further research is needed to confirm these associations and understand their role in PSP pathogenesis.
Conclusions:
- Environmental and lifestyle factors play a significant role in the risk of developing progressive supranuclear palsy (PSP).
- Understanding these risk factors can inform public health strategies and clinical interventions for PSP prevention and management.
Related Concept Videos
01:15Parkinson's Disease: Overview
1.0K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
1.0K
01:24Parkinson's Disease: Treatment
615
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
615
01:37Neural Regulation
40.8K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
40.8K
01:29Biological Causes of Schizophrenia
218
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
218
01:28Disorders of the Nervous Tissue
2.0K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
2.0K
01:29Psychological and Sociocultural Causes of Schizophrenia
254
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
254