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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
Exploiting a New Approach to Destroy the Barrier of Tumor Microenvironment: Nano-Architecture Delivery Systems
Yanting Sun1, Yuling Li2, Shuo Shi1
1Department of Oncology, Shanghai East Hospital, Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, Shanghai 200120, China.
Abstract:
Recent findings suggest that tumor microenvironment (TME) plays an important regulatory role in the occurrence, proliferation, and metastasis of tumors. Different from normal tissue, the condition around tumor significantly altered, including immune infiltration, compact extracellular matrix, new vasculatures, abundant enzyme, acidic pH value, and hypoxia. Increasingly, researchers focused on targeting TME to prevent tumor development and metastasis. With the development of nanotechnology and the deep research on the tumor environment, stimulation-responsive intelligent nanostructures designed based on TME have attracted much attention in the anti-tumor drug delivery system. TME-targeted nano therapeutics can regulate the distribution of drugs in the body, specifically increase the concentration of drugs in the tumor site, so as to enhance the efficacy and reduce adverse reactions, can utilize particular conditions of TME to improve the effect of tumor therapy. This paper summarizes the major components and characteristics of TME, discusses the principles and strategies of relevant nano-architectures targeting TME for the treatment and diagnosis systematically.
Insights
Targeting the tumor microenvironment (TME) with nanotechnology offers a promising strategy for cancer therapy. Stimulation-responsive nanostructures leverage TME characteristics to enhance drug delivery, improving efficacy and reducing side effects.
Area of Science:
- Oncology
- Nanotechnology
- Biomedical Engineering
Background:
- The tumor microenvironment (TME) significantly influences tumor progression, including occurrence, proliferation, and metastasis.
- Key TME alterations include immune cell infiltration, altered extracellular matrix, neovasculature, enzymatic activity, acidity, and hypoxia.
- Targeting the TME is a growing focus for developing novel anti-cancer strategies.
Purpose of the Study:
- To summarize the major components and characteristics of the tumor microenvironment.
- To discuss the principles and strategies of nano-architectures designed to target the TME.
- To review the application of TME-targeted nanotherapeutics in cancer treatment and diagnosis.
Main Methods:
- Literature review of recent findings on tumor microenvironment characteristics.
- Analysis of nanotechnology advancements in developing stimulation-responsive nanostructures.
- Systematic discussion of TME-targeting strategies for drug delivery and diagnosis.
Main Results:
- The tumor microenvironment presents unique conditions exploitable for targeted therapies.
- Stimulation-responsive nanostructures can be designed to respond to specific TME stimuli.
- TME-targeted nanotherapeutics demonstrate potential for enhanced drug accumulation at tumor sites.
- These approaches aim to improve anti-tumor efficacy while minimizing systemic toxicity.
Conclusions:
- Nanotechnology-based strategies targeting the tumor microenvironment are crucial for advanced cancer therapy.
- Intelligent nanostructures offer precise drug delivery, enhancing treatment outcomes.
- Further research into TME-targeted nanotherapeutics holds significant promise for improved cancer treatment and diagnosis.
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