Serological Biomarkers and Diversion Colitis: Changes after Stimulation with Probiotics

Area of Science:

• Gastroenterology
• Colorectal Surgery
• Inflammation Research

Background:

• Diversion colitis is colon inflammation after temporary stoma creation.
• It's linked to changes in serum inflammatory markers.
• Understanding these changes is crucial for patient management.

Purpose of the Study:

• To assess how probiotics affect inflammatory biomarkers before ileostomy closure.
• To explore the link between diversion colitis severity and blood inflammatory markers.

Main Methods:

• A prospective, randomized, double-blind, controlled study.
• Patients with diversion colitis received probiotics (SG) or placebo (CG) before ileostomy closure.
• Endoscopic, histological, and blood biomarker changes were monitored.

Main Results:

• Probiotic group (SG) showed decreased C-reactive protein (CRP), Neutrophil/Lymphocyte Ratio (NLR), and Monocyte/Lymphocyte Ratio (LMR).
• SG had increased transferrin and Platelet/Lymphocyte Ratio (PLR) post-stimulation.
• Probiotic use led to a lower modified Glasgow prognostic score.

Conclusions:

• Diversion colitis severity correlates with inflammatory biomarker alterations.
• Probiotic stimulation before surgery aids early normalization of these biomarkers.
• Probiotics show promise in managing diversion colitis and improving surgical outcomes.