Sweet Cherries as Anti-Cancer Agents: From Bioactive Compounds to Function

Area of Science:

• Nutritional Science
• Oncology
• Food Science

Background:

• Sweet cherries (Prunus avium L.) are globally valued for taste and nutrition.
• Phytochemical composition varies by region and cultivar, impacting nutrient bioavailability.
• Cherry extracts are rich in bioactive phenolic compounds with significant health benefits.

Purpose of the Study:

• To review the anticarcinogenic potential of sweet cherries.
• To detail their phytochemical profile, bioaccessibility, and bioavailability.
• To explore their effects on key cancer processes.

Main Methods:

• Literature review of phytochemical composition and bioactivity.
• Analysis of research on sweet cherry effects against cancer hallmarks.
• Synthesis of data on oxidative stress, inflammation, cell proliferation, apoptosis, invasion, metastasis, and metabolic alterations.

Main Results:

• Sweet cherries contain phenolic compounds with demonstrated bioactivity.
• Evidence supports their role in suppressing oxidative stress and inflammation.
• Emerging research indicates effects on metabolic reprogramming and other cancer hallmarks.

Conclusions:

• Sweet cherries exhibit significant anticarcinogenic properties.
• Their bioactive compounds show promise in cancer prevention and treatment.
• Further research can validate their use as a dietary supplement or adjunct therapy.