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Serum Periostin as a Potential Biomarker in Pediatric Patients with Primary Hypertension
Michał Szyszka1, Piotr Skrzypczyk2, Anna Stelmaszczyk-Emmel3
1Department of Pediatrics and Nephrology, Doctoral School, Medical University of Warsaw, 02-091 Warsaw, Poland.
Insights
Serum periostin levels were lower in children with primary hypertension. Periostin concentration correlated with blood pressure and arterial stiffness, but its role as a biomarker requires further investigation.
Area of Science:
- Biochemistry
- Pediatric Cardiology
- Biomarker Research
Background:
- Periostin is implicated in tissue repair and remodeling.
- Primary hypertension (PH) in children is a growing concern.
- Identifying reliable biomarkers for pediatric PH is crucial for early detection and management.
Purpose of the Study:
- To evaluate serum periostin concentration as a potential biomarker in pediatric patients with primary hypertension.
- To assess the correlation between serum periostin levels and indicators of cardiovascular health in children.
Main Methods:
- Serum periostin, blood pressure, arterial damage markers, and biochemical data were measured in 50 children with PH and 20 healthy controls.
- Univariate and multivariate analyses were performed to identify correlations.
- Arterial stiffness was assessed using aortic pulse wave velocity (aPWV).
Main Results:
- Children with PH exhibited significantly lower serum periostin levels compared to healthy controls (p=0.038).
- Serum periostin negatively correlated with peripheral, central, and ambulatory blood pressure, and aPWV in the overall cohort.
- Multivariate analysis revealed significant correlations between periostin and age, uric acid, BMI Z-score, HDL-cholesterol, and triglycerides.
Conclusions:
- The study did not definitively establish serum periostin as a biomarker for elevated blood pressure or arterial damage in pediatric PH.
- Age, BMI, uric acid, and lipid profiles are significant factors influencing periostin levels in pediatric patients.
- Further research is needed to elucidate the precise role of periostin in pediatric primary hypertension.
Abstract:
Experimental studies suggest that periostin is involved in tissue repair and remodeling. The study aimed to evaluate serum periostin concentration as potential biomarker in pediatric patients with primary hypertension (PH). We measured serum periostin, blood pressure, arterial damage, biochemical, and clinical data in 50 children with PH and 20 age-matched healthy controls. In univariate analysis, children with PH had significantly lower serum periostin compared to healthy peers (35.42 ± 10.43 vs. 42.16 ± 12.82 [ng/mL], p = 0.038). In the entire group of 70 children serum periostin concentration correlated negatively with peripheral, central, and ambulatory blood pressure, as well as with aortic pulse wave velocity (aPWV). In multivariate analysis, periostin level significantly correlated with age (β = -0.614, [95% confidence interval (CI), -0.831--0.398]), uric acid (β = 0.328, [95%CI, 0.124-0.533]), body mass index (BMI) Z-score (β = -0.293, [95%CI, -0.492--0.095]), high-density lipoprotein (HDL)-cholesterol (β = 0.235, [95%CI, 0.054-0.416]), and triglycerides (β = -0.198, [95%CI, -0.394--0.002]). Neither the presence of hypertension nor blood pressure and aPWV influenced periostin level. To conclude, the role of serum periostin as a biomarker of elevated blood pressure and arterial damage in pediatric patients with primary hypertension is yet to be unmasked. Age, body mass index, uric acid, and lipid concentrations are key factors influencing periostin level in pediatric patients.
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