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Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

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A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

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Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
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The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Thermoregulation01:26

Thermoregulation

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The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
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Types of Fever01:25

Types of Fever

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Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
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Related Experiment Video

Updated: Nov 3, 2025

Protocol for Long Duration Whole Body Hyperthermia in Mice
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Hyperthermia and Tumor Immunity.

Ather Adnan1, Nina M Muñoz2, Punit Prakash3

  • 1Texas A&M Health Science Center, Texas A&M College of Medicine, Houston, TX 77030, USA.

Cancers
|June 2, 2021
PubMed
Summary
This summary is machine-generated.

Thermal ablation, a local cancer treatment, shows promise for widespread metastatic disease by potentially enhancing systemic immunotherapy effects. This approach may offer new clinical benefits for patients with advanced cancer.

Keywords:
ablationcancerhyperthermiaimmunotherapy

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Area of Science:

  • Oncology
  • Immunology
  • Interventional Radiology

Background:

  • Thermal ablation is standard for solitary or limited metastatic cancer.
  • Its role in widely metastatic disease is historically limited due to risk-benefit considerations.
  • Recent advances in immunotherapy have reframed the potential of local therapies.

Purpose of the Study:

  • To review the unmet need for adjuvant interventions in cancer care.
  • To explore the immunologic implications of thermal ablation in metastatic disease.
  • To summarize preclinical and clinical data on the immunogenicity of thermal ablation.

Main Methods:

  • Literature review of existing preclinical and clinical studies.
  • Analysis of the role of local cancer therapies in systemic immunity.
  • Discussion of immune checkpoint inhibitors and their interaction with ablation.

Main Results:

  • Local cancer therapies, including thermal ablation, can induce systemic immune responses.
  • Emerging data suggest thermal ablation may enhance the efficacy of systemic immunotherapies.
  • There is a growing interest in leveraging ablation for its immunomodulatory effects.

Conclusions:

  • Thermal ablation may offer significant clinical benefits for patients with widely metastatic disease.
  • Ablation can serve as an adjuvant intervention to broaden the impact of systemic immunotherapies.
  • Further research into the immunogenicity of thermal ablation is warranted.