Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

17.1K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.1K
Viral Recombination00:57

Viral Recombination

24.2K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
24.2K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.7K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.7K
Viral Mutations00:36

Viral Mutations

36.5K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
36.5K
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

284
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
284

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of Selected Genetic Variants in CYP1A1, CYP2D6, NAT1 and NAT2 with Endometrial Cancer Risk: A Preliminary Case-Control Study.

International journal of molecular sciences·2026
Same author

Amino Acid-Fatty Acid Profile as a Novel Predictive Method in the Assessment of Diagnosis and Treatment Efficacy of Anxiety-Related Disorders and Mood Disorders.

International journal of molecular sciences·2026
Same author

Analysis of correlation between RAD51 172G/T polymorphism and colorectal cancer in the Polish population.

Polski przeglad chirurgiczny·2026
Same author

Genetic Association of RXFP2 T222P Variant With Cryptorchidism: A Meta-Analytic Study.

Andrology·2026
Same author

Microglia, Astrocytes, and Oligodendrocytes in Parkinson's Disease: Neuroinflammatory Crosstalk and Emerging Therapeutic Strategies.

Biomolecules·2026
Same author

Multi-Strain Probiotic Improves Tryptophan Metabolism and Symptoms in Chronic Fatigue Syndrome Patients with Co-Occurring Irritable Bowel Syndrome: An Open-Label Pilot Study.

Nutrients·2026

Related Experiment Video

Updated: Nov 3, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

3.0K

The Emerging Concern and Interest SARS-CoV-2 Variants.

Edyta Janik1, Marcin Niemcewicz1, Marcin Podogrocki1

  • 1Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.

Pathogens (Basel, Switzerland)
|June 2, 2021
PubMed
Summary

New severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants emerge and pose public health risks. This analysis details key SARS-CoV-2 variants, focusing on infectivity, severity, mutations, and immune susceptibility.

Keywords:
COVID-19SARS-CoV-2mutationsvariants

More Related Videos

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.5K
Quantification and Whole Genome Characterization of SARS-CoV-2 RNA in Wastewater and Air Samples
09:26

Quantification and Whole Genome Characterization of SARS-CoV-2 RNA in Wastewater and Air Samples

Published on: June 30, 2023

1.3K

Related Experiment Videos

Last Updated: Nov 3, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

3.0K
Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.5K
Quantification and Whole Genome Characterization of SARS-CoV-2 RNA in Wastewater and Air Samples
09:26

Quantification and Whole Genome Characterization of SARS-CoV-2 RNA in Wastewater and Air Samples

Published on: June 30, 2023

1.3K

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the COVID-19 pandemic, declared by the WHO in March 2020.
  • SARS-CoV-2, like other RNA viruses, undergoes continuous mutation, leading to the emergence of new variants.
  • While numerous variants exist, only a subset poses significant public health risks due to increased transmissibility or severity.

Purpose of the Study:

  • To summarize critical information on SARS-CoV-2 variants.
  • To provide insights into variant infectivity, disease severity, genetic mutations, and susceptibility to immune responses.
  • To highlight variants requiring close monitoring.

Main Methods:

  • Classification of SARS-CoV-2 variants by the Centers for Disease Control and Prevention (CDC) and SARS-CoV-2 Interagency Group (SIG).
  • Categorization into "variants of concern," "variants of interest," and "variants of high consequence."
  • Review of scientific literature and surveillance data on identified variants.

Main Results:

  • Three variants of concern (VOCs) identified: B.1.1.7, B.1.351, and P.1.
  • Four variants of interest (VOIs) identified: B.1.526, B.1.525, B.1.427/B.1.429, and P.2.
  • These variants are characterized by specific mutations affecting their biological properties.

Conclusions:

  • Ongoing monitoring of SARS-CoV-2 variants is crucial for public health.
  • Understanding variant characteristics is essential for developing effective control strategies.
  • Further research is needed to fully assess the impact of emerging variants on disease transmission and treatment.