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Recent Progress in Transdermal Nanocarriers and Their Surface Modifications
Zhixi Yu1, Xinxian Meng1, Shunuo Zhang1
1Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, 639 Zhizaoju Rd, Shanghai 200011, China.
Molecules (Basel, Switzerland)
|June 2, 2021
Summary
Surface modification of transdermal nanocarriers enhances drug delivery efficiency and skin penetration. This review explores strategies for optimizing transdermal drug delivery systems (TDDS) for improved therapeutic outcomes.
Area of Science:
- Pharmaceutical Sciences
- Biomaterials Engineering
- Nanotechnology
Background:
- Transdermal drug delivery systems (TDDS) offer advantages like convenience and reduced systemic side effects.
- Transdermal nanocarriers represent a promising advancement in TDDS due to their non-invasive nature and high drug delivery efficiency.
- Current challenges include optimizing nanocarriers to penetrate the skin barrier, control drug release, and achieve targeted delivery.
Purpose of the Study:
- To review the latest developments in transdermal nanocarriers for drug delivery.
- To summarize the transdermal mechanisms of various nanocarrier systems.
- To focus on surface modification strategies for functionalizing transdermal nanocarriers.
Main Methods:
- Literature review of transdermal nanocarrier research.
- Analysis of nanocarrier transdermal mechanisms.
- Categorization of surface modification techniques and their functions.
Main Results:
- Surface modification is a key strategy for enhancing nanocarrier performance in TDDS.
- Modified nanocarriers demonstrate improved skin penetration, controlled release kinetics, and targeting capabilities.
- Various surface functionalization approaches can be tailored to specific therapeutic needs.
Conclusions:
- Surface modification significantly optimizes transdermal nanocarriers for improved drug delivery.
- Functionalized nanocarriers hold great potential for overcoming skin barrier limitations and achieving targeted transdermal therapies.
- Further research into tailored surface modifications can unlock the full clinical potential of TDDS.
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